Cheers
Oops, the 'pear' got hyper-linked to a Glossary item
Upon recommendation, this discussion has been re-directed, from the Teaching with Moodle MOOC Thread to here. I am assuming the previous comments from over there, are still accessible because I want to try out the suggestions, and then get some more help, when - not if - it all goes pear-shaped 
I'm just pasting Anne's initial question from the MOOC here:
I would like to make Moodle more accessible to 'reluctant readers'. I am using v2.6 at work, but have v2.8 downloaded at home. I have tried the Accessibility buttons, but they just knock out any existing background colours. I have also tried the plugins on various Browsers. I'd like to make it easy for staff to use, but the only solution I can find is to tweak the HTML editor and use tables. I am not the Admin-guy, but I think we have the Clean Theme, it uses dark grey lettering with off-white background.
I did come across the Topic:Colour plugin, which I installed at home, but if you create a resource like a book or page, the background colour is not transferred. It reverts to white.
In a ideal world, I'd like the same colour to run through all the resources in one particular course (ie Maths for Beginners) and then a different colour for another course (ie Intermediate Maths), so the students have visual clues to their location - like arriving in a new town, you can work out where you are from just looking around, if that makes sense!
To clarify my question, a bit:
Given all this talk about 'Personalised Learning', is it possible for students to change the background colour, to something that makes the text more accessible for them? Specifically, I am thinking about dyslexic learners, where it has been identified that pale blue, or cream paper works best for them. I have tried the Accessibility Buttons on Moodle, and the Plugins on various Browsers, but the results are not quite right. They tends to knock out all existing background colours - which means the disadvantaged user is still missing out. It's a bit like wearing sunglasses, the sky might be less bright, but it is still blue.
Of course, such students could be supplied with transparent overlaps for their monitors. But somehow, this solution seems a bit primitive and pre-digital. And it wouldn't work so well, if they then moved devices, eg from wide-screen PC to hand-held iPad.
Although our Moodle theme has been designed to comply with all the DDA and Equal Opps stuff, it still relies on the assumption that 'one-size-fits-all', and anyone who is slightly different, be they dyslexic, a reluctant reader or 'just a luddite' is probably going to find the whole experience of Moodling, a little bit unpleasant.
I will have a go at creating 'clones' or multiple themes, for different people. But again, this solution takes the agency away from the user and implies in a traditional-teacher-voice, "I know what best". In a BYOD world, how far can Moodle accommodate different expectations?
Cheers