I have always managed to avoid SELinux. Long may it continue 
Howard Miller
Beiträge von Howard Miller
Doesn't that force Moodle to connect using TCP/IP rather that through a socket?
I'm moving this to the Hardware and Performance forum.
Also, we don't know. It might be useful to read through similar past questions. The issue is that it entirely depends on what these users are doing. And... you said 10,000 to 1,500 concurrent users, so I think you have missed or added a zero somewhere. Even then, those are big numbers and I would, firstly, ask you to justify them and, secondly, ask you to think about contacting a Moodle Partner who is experienced in running large Moodle installations like that.
Also, we don't know. It might be useful to read through similar past questions. The issue is that it entirely depends on what these users are doing. And... you said 10,000 to 1,500 concurrent users, so I think you have missed or added a zero somewhere. Even then, those are big numbers and I would, firstly, ask you to justify them and, secondly, ask you to think about contacting a Moodle Partner who is experienced in running large Moodle installations like that.
It only claims up to 4.1 support. However, have you tried it with 4.2? It may just not have been tested (yet).
To answer the second part, you may want to read, https://github.com/andstenberg-rs/moodle-block_readspeaker_embhl/blob/main/README.md