I would like to point out a similar discussion on improving the performance of a Moodle site by minimizing files sizes. Unfortunately, using compression on a server, especially GZIP, causes problems with IE 6. So if you have to support IE 6, the best option is to minimize javascript and CSS. Please see http://moodle.org/mod/forum/discuss.php?d=115967#p509343
Hardware and performance
A Proposal to Speed Up Moodle Sites Greatly
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