When I had read the article I thought the aspect of loading huge libraries might be interesting for Moodle.
With more and more people being aware that less JavaScript is better than more is there a discussion at Moodle HQ or somewhere about the amount of JavaScript transferred and initialized in the browser to get Moodle working? The tendency in Moodle I see seams to be not to care about the amount of data. With the decision to load "simpleyui" as the default huge parts of the library are loaded by default. And with the decision to include jQuery it is easy to add an additional library which does basically the same as YUI but offers much more solutions because it is wider used.
I know that these decisions have been made due to common demand. But when we think about mobile use with less bandwidth and less powerful devices these decisions may need to be rethought.
It would be interesting to hear from the front-end team if they see JavaScript (and CSS) use as it is now as an issue and if so if they have started to think about possible solutions.