Ballpark for an LMS administrator (Blackboard/Sakai/Moodle/WebCT/Angel) is around 1 FTE for every 10,000 users. Now if that admin is also doing course building, training, etc. you'll want to go to 1/2 - 2. But it is highly variable depending on how the site is used, how hosted, etc. I know of 50,000 user corporate sites, doing compliance training with just a few courses, who run Moodle with 1/2 FTE or less.
The numbers above assume you have an IT dept. or running Moodle as SAAS - sometimes the Moodle admin has to setup and administer the servers also, and that can add more hours depending how it is done.
If you are doing custom development also, then you'll want to add an FTE for a programmer or several*, depending on how much you want to do (most users don't do any customization - similarly you can have programmers make Building Blocks for Blackboard, but most BB sites don't.)
Of course you can also contract with a Moodle Partner to do most of the things above for you, and still save much more than you would spend on a commercial LMS.
*Sometimes I've seen people try to combine programmer/SysAdmin/Support and save some $$- I don't usually recommend that as the skillsets and ideal personality types are pretty different.