It would be nice to see some commitment to following the standard front-end best practices that are encoded in Bootstrap (of any version, and they're shared with most popular alternatives) but for whatever reason that seems a hard sell. We already have Bootstrap 2 as the default theme but struggle to follow their best practices in things like semantic alerts so I suppose a shift to 3 wouldn't necessarily fix that either.
There would definitely be benefits to the wider Moodle ecosystem of a clear frontend vision committed to following Bootstrap, with enough forward planning to cope with upgrades, like many other comparable projects have, but frankly, compared with the lack of renderers and the prehistoric state of much of the core HTML (We still have tables for layout!) it's a minor problem.
My main worry is, that without the guidance of Bootstrap's design decisions, the API for the newly created renderers will be terrible. Again, in theory we already have Bootstrap 2 as a core component, but it's not helped so far with attempts to rationalize the existing renderer APIs into something simple, sane and modern. Though that, like renderers generally, has not been a big focus of work so far though there was some discussion about it. Hopefully any new renderer work will start with figuring out the right way to do it, and not be too constrained by existing practice in Moodle, down to the level of recreating obvious bugs and design flaws in new code.