In case anyone may find it useful we finally decided to go with nginx and fpm.
We did miss XSendFile with nginx that give us a big increase in performance. Also we found
pm.max_children = 5 too small, so we increased it to 20.
However we've found a bottleneck in network communication between Moodle and our DB that can be seen as peaks in our graphic (increase in request time). It's just 100Mb/s and we will increase it to 1GB.
We also tested with 1500 users and we get aproximately 150 req/s (Moodle pages) with average request times of 1 sec. Activating APC as App cache (we use just one frontend) and Redis for session cache we improve request times for just 10%, however the machine feels more stable (cpu).