The questions are, are you happy with your current setup? Can you troubleshoot it if anything goes wrong? Can you apply security patches/upgrades easily? In other words, do you "master" your current setup?

If the aswer to any of these questions is 'no', maybe a preformatted distribution is the way to go (you'll have to master that distribution too, but at least in theory you should be able to find help more easily).

Me, I'm using Debian. Not so much for the technical merits, but for the 'ethical' aspects of that distribution.

Saludos. Iñaki.