Updates and security: You should plan to periodically apply updates to your site's source code to ensure you have any bug fixes and security updates. If your site's source code has been modified then every time you update the source code you will need to make this additional modification. It's just something you need to be aware of. Hopefully MDL-63770 will get fixed in a future update and you'll no longer need to do this.
If you're going to change the site's address, I'd recommend doing that now before anyone starts adding links within the site using the old address (although you can change these). But you should just need to change wwwroot in config.php.