How big is your college? If it is a 10k college, as in the example of Usman, then you are a professional system administrator. A professional comes with his platform, if he has doubts about his platform, something is wrong. Or, is it a school of a couple of hundred (potential) users and your are a teacher who is released from work for an hour or two per week to look try Moodle? You know Windows as a desktop but not as a server. And assume a server is the same. (You can't be famlier with Windows Server 2016, "The final release date for the server is expected to be in Q3 2016, that is, not released simultaneously with the client operating system Windows 10 as was the case with the last three operating system releases." https://en.wikipedia.org/wiki/Windows_Server_2016
). The two types of "administrators" need differing answers.
>Hardware is no problem for me and my budget is good.
It doesn't solve all the problems. For example, whether you run 1 kW 7x24 or 100 W 7x24 makes a huge difference in the climate.
> it seems Moodle is more happy in a Linux environment
Moodle is PHP on the server side, that is not what makes the difference. It is the general efficiency of the LAMP stack!
> where as I am more comfortable in a Windows environment.
If you are the Windows-type, you won't be happy with Linux.
> I also read there might be backup issues with Windows,
Could you provide your evidence.
> I was originally thinking along the lines of Windows Server 2016, IIS 10 and of course Moodle. I also like the remote access Windows would give me as I travel a lot and I am not sure if Linux gives this.
Then you have no idea of Linux (or Unix). (For the sake of completeness: The answer is the combination of terminal and shell.)
> Also it seems there are different Linux versions and I do not know which is best suited for Moodle. Ugh. I am not adverse to learning Linux if need be. I just need to get it right.
Oh, the Linux question is answered. If you are not even a beginner in Linux today, don't dream of running your school's LAMP server tomorrow!