While not wanting to sound like an old Unix geek telling you to search the archives, you should search the archives
There are limitations with Safe Mode - some stuff won't (or might not) work. There has been loads of discussion on this in the past and doing a forum search for 'safe mode' should enlighten you a lot!
But, to cut a long story short, if you can possibly avoid it, don't use a safe mode setup.
Installing and upgrading help
PHP in Safe Mode
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