As Guillermo says, you need to know how to install Moodle and I'm guessing that perhaps you need to know a few basic concepts? (excuse me if not)
Your 'Microsoft Expressions' seems to be a web page authoring tool? I don't think that will help you, because Moodle is ALREADY a webpage (website actually). For that reason you need a webserver!
It is possible to run Moodle on a personal computer, but that is just an emulation of a real life webserver.
If you need some constructive help, it might be an idea to let us know why you want to use Moodle, what you hope to achieve and exactly in which situation you are imagining using it. I'm sure there will be lots of answers from people from similar backgrounds.
Hope that helps
PS Take a look at my 'open moodle' if you need ideas http://stories4learning.com/moodle . To set something like that up on the world wide web, you need a hosting service (costs monthly money) and you then upload your Moodle data to the server. If you just want Moodle locally within a classroom or school, you'll need a 'server PC' to allow Moodle to be accesed by several computers in parallel.