I wanted to let everyone know that there is now a new block available for Moodle 2.0+, that allows you to drag files directly from your desktop onto a Moodle course section (where they appear as resources).
This works with recent versions of Firefox or Chrome (and IE10 may work, once it is released).
The official Modules & Plugins database entry is here: http://moodle.org/mod/data/view.php?d=13&rid=4963 (once it has been approved)
You can read some documentation here: http://docs.moodle.org/20/en/Drag_and_drop_upload_block
or, you can download it from Github: https://github.com/davosmith/moodle-block_dndupload/zipball/master